Rating the most effective berberine dietary supplements of 2022


Berberine is an natural complement with a historical past that’s 1000’s of years lengthy.

It’s been used and researched to deal with every little thing from joint ache to weight reduction to controlling diabetes in folks with insulin insensitivity.

Berberine’s mechanism of motion is complicated, nevertheless it seems to change the best way your physique’s mitochondria generate vitality, which could point out why it’s useful for such all kinds of illnesses.

For those who’re in search of a top quality weight reduction complement sourced from an natural treatment, berberine is price a glance.

We’ve examined what’s obtainable in the marketplace proper now and provide you with the highest ten, ranked in line with efficacy.

Why You Ought to Belief Us

    Our advisory panel and our analysis group rank the most effective well being merchandise and dietary supplements primarily based on efficiency, label accuracy, and the efficacy of the elements within the merchandise.


Final up to date: September 22, 2022
Berberine dietary supplements thought-about: 25
Hours of analysis: 45
Consultants reviewed: 10
Scientific papers referenced: 32


Greatest General

1. Nuzena Berberine Pure +

  • Helps coronary heart well being, blood sugar management, and gastrointestinal operate
  • Every veggie capsule boasts 600 mg of extremely pure and extremely concentrated berberine
  • Its purity is independently verified by third-party lab testing
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Greatest for intestine well being

2. Thorne Analysis Berberine

  • Pure product with a minimal quantity of extraneous elements
  • Probably the greatest berberine dietary supplements on the market that is available in a vegetarian capsule
  • 500 mg per capsule
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Greatest for ladies

3. aSquared Diet Berberine

  • Extremely pure berberine complement in a gelatin capsule
  • Gives a really stable 500 mg of berberine per capsule at a 60% focus
  • Has a superb fame for purity and high quality in its dietary supplements
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Greatest for weight reduction

4. Integrative Therapeutics Berberine Advanced

  • It makes use of three totally different plant species as sources of berberine
  • Mixed with a number of of the opposite associated compounds within the plant which might be bioactive
  • Gluten-free
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5. We Like Nutritional vitamins Berberine

  • It has a simplistic design and allergen-free certification
  • The one different elements are gelatin and rice flour
  • Gluten-free, dairy-free, egg-free, and soy free
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6. Divine Bounty Berberine

  • 600 mg per capsule
  • Gives 20% extra berberine per serving than most of its different rivals
  • It is available in a vegetarian capsule
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7. Naturebell Berberine Plus

  • Gives a stable berberine complement with a excessive dose of 600 mg per capsule
  • Good purity and complement design
  • Wheat-free, soy-free, dairy-free, and egg-free
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8. Dr. Whitaker’s Medical Grade Berberine

  • Branded and clinically grade
  • 500 mg of berberine per capsule
  • Gelatin capsule
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  • Has superior absorption properties
  • 500 mg of berberine per capsule
  • Brown rice focus filler within the vegetarian capsule
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  • 600 mg berberine complement
  • Vegetarian capsule
  • It’s licensed freed from many frequent allergens like gluten and soy
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1. Nuzena Berberine Pure +

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If you wish to leverage the advantages of berberine for higher coronary heart well being, blood sugar management, and gastrointestinal operate, look no additional than Nuzena Berberine Pure +. 

Every veggie capsule boasts 600 mg of extremely pure and extremely concentrated berberine, placing it on the high of our checklist thanks each to its excessive dosage and to its excessive purity. On high of that, its purity is independently verified by third-party lab testing, and it’s licensed non-GMO, gluten-free, and vegan-friendly.

For all of those causes, Berberine Pure + by Nuzena is our primary choose for 2021.

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2. Thorne Analysis Berberine

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Thorne Analysis is a widely known identify within the rarer, much less frequent natural extracts as a result of they virtually at all times make a top quality, pure product with a minimal quantity of extraneous elements.

That’s actually the case right here, as this is without doubt one of the greatest berberine dietary supplements on the market that is available in a vegetarian capsule. At 500 mg per capsule, it doesn’t skimp on the dosage both.

3. Integrative Therapeutics Berberine Advanced

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Not like many different corporations, Integrative Therapeutics is doing one thing progressive with its berberine complement. It makes use of three totally different plant species as sources of berberine, and considered one of them is mixed with a number of of the opposite associated compounds within the plant which might be bioactive.

Which means that this berberine complement could possibly be extra prone to work if others have failed you, although if all you need is 100% pure berberine, there are higher choices in the marketplace.

4. NOW Dietary supplements Berberine Glucose Assist

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NOW Dietary supplements makes a fairly stable berberine complement that’s particularly geared in direction of utilizing berberine for blood sugar management.

It accomplishes this by delivering its berberine content material in MCT oil, a superb ship platform for the lipid-soluble biologically lively compounds in berberine.

The one draw back? This methodology of supply places a restrict on the dosage; every capsule delivers solely 400 mg of berberine

5. We Like Nutritional vitamins Berberine

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The dosage of berberine on this complement (600 mg per capsule) is middle-of-the-road, however its simplistic design and its allergen-free certification make it a really stable selection.

The one different elements are gelatin (for the capsule–sorry, vegetarians) and rice flour, and the truth that it’s gluten, dairy, egg, and soy free are all to its profit.

6. Divine Bounty Berberine

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For these in search of a excessive dosage berberine complement, Divine Bounty is an effective selection. With 600 mg per capsule, it offers 20% extra berberine per serving than most of its different rivals.

Add to that the truth that it is available in a vegetarian capsule and doesn’t have a lot in the best way of additional fillers and stabilizers, and also you’ve received a profitable method for individuals who want the next than ordinary dose of berberine.

7. Naturebell Berberine Plus

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Naturebell offers a stable berberine complement with a excessive dose of 600 mg per capsule, which is sweet for extra aggressive supplementation routines taking pictures for 1200 mg per day in two separate doses. Apart from this, the purity and complement design is sweet however not the best possible.

8. Dr. Whitaker’s Medical Grade Berberine

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Although it’s branded as scientific grade, this berberine complement doesn’t look like of upper dosage or high quality than the rest in the marketplace.

It has the same old 500 mg of berberine per capsule, and the capsules are product of gelatin together with a couple of further fillers and stabilizers not discovered within the rivals, making it onerous to justify rating this complement any greater.

9. Toniq Berberine

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Toniq delivers a extremely purified model of berberine extract at a stable 500 mg dosage. It’s a terrific go-to choice if you need a easy and pure berberine complement at a typical dosage, although the capsule has a couple of extra binders and fillers than we’d prefer to see.

10. Sunergetic Berberine

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Sunergentic has a high-dose 600 mg berberine complement that’s delivered in a vegetarian capsule.

It’s additionally licensed freed from many frequent allergens like gluten and soy, although the principle draw back of the berberine complement from this lesser-known complement producer is its reliance on silica as a filler for its capsules. Increased-quality manufacturers will go for one thing extra pure, like rice flour.

Class winners

Greatest berberine general: Nuzena Berberine Pure +

With 600 mg of berberine per capsule, unbiased lab verification for purity, and no extraneous elements, Nuzena is a superb selection. Excessive dose, super-pure, and straightforward to make use of.

Greatest berberine for intestine well being: Thorne Analysis Berberine

If you’re utilizing berberine for intestine issues, just like the bacterial overgrowth linked to SIBO, you desire a berberine complement that’s freed from any extraneous elements. That’s why we advocate Thorne Analysis Berberine for intestine well being—its ultra-simple complement design makes it well-suited for this utility.

Greatest berberine for weight reduction: Integrative Therapeutics Berberine

Integrative Therapeutics offers berberine alongside two different natural extracts for digestive and metabolic well being: goldenseal and Oregon grape extracts. These could possibly be helpful for stopping among the troublesome gastrointestinal unintended effects that may come together with beginning a weight reduction food regimen. 

Greatest berberine for ladies: NOW Dietary supplements Berberine Glucose Assist

Girls profit from the extremely bioavailable supply of berberine on this complement, with simpler absorption because of the MCT oil used to dissolve the lively compounds in berberine. The five hundred mg dosage is an effective match for a lot of girls as nicely

Greatest berberine for coronary heart well being: Thorne Analysis Berberine

Berberine has been utilized in a couple of scientific research to scale back blood lipids and blood stress, which might help lower your threat of coronary heart illness. To observe the protocols from these research as intently as attainable, go for a pure and concentrated berberine complement like Thorne Analysis Berberine, which boasts 500 mg of 85% berberine extract.

Greatest berberine for blood sugar management: Nuzena Berberine Pure + 

One in all berberine’s hottest functions helps to regulate blood sugar, and the high-dose formulation of Nuzena Berberine Pure + is completely fitted to this use case: its 600 mg of concentrated berberine extract per capsule leads the trade in dosage. 

Who can purchase berberine?

Berberine seems to modulate the best way your physique processes and makes use of vitality. Meaning berberine dietary supplements are tailor-made for a couple of particular use instances:

Individuals who wish to management their blood sugar extra successfully. Berberine has been studied most intently as a approach to assist deal with insulin insensitivity in individuals who have sort two diabetes or who’ve metabolic syndrome. Berberine may assist you enhance blood glucose regulation and battle again in opposition to metabolic dysfunction.

Individuals who wish to fight the unfavorable well being results of weight problems. By itself, berberine just isn’t a implausible weight reduction complement, nevertheless it does do a reasonably good job serving to to ameliorate the unfavorable well being results related to being chubby.

It would assist decrease your physique fats proportion, nevertheless it’s far stronger at bettering well being points generally related to an unhealthy food regimen and extreme physique weight, equivalent to excessive ldl cholesterol and excessive blood lipids.

Some analysis means that berberine works for weight reduction, however not in addition to among the extra high-powered compounds for weight reduction like inexperienced tea extract

Individuals with irritable bowel syndrome. Curiously, berberine additionally has a devoted core of advocates amongst individuals who have irritable bowel syndrome.

Whereas the mechanism of motion right here just isn’t totally clear, scientific analysis does help the usage of berberine to scale back among the signs of irritable bowel syndrome, so if in case you have gastrointestinal issues attributable to IBS, you could have success utilizing berberine as nicely.

How we ranked

Berberine’s specialised makes use of knowledgeable our rating process: since there are a number of scientific trials on utilizing berberine, we have been in a position to examine the supply mechanism, dosage, and purity of the merchandise we thought-about to the gold commonplace of what’s utilized in scientific analysis. Particularly, we seemed for:

A concentrate on delivering berberine. As a result of berberine is particularly geared in direction of sure well being issues, and since many of the proof for it comes from scientific trials that used pure berberine extracts of their experiments, we required the berberine dietary supplements in our rankings to ship solely berberine as their lively ingredient.

Whereas it’s not essentially true that berberine should be taken to the exclusion of all different dietary supplements, that is how it’s normally prescribed in scientific analysis. No merchandise that included non-berberine lively elements made it into our rankings.

Proof-based berberine dosage. Subsequent, after specializing in berberine-specific dietary supplements, we seemed on the dosage.

For the reason that analysis on berberine usually makes use of 900-1500 mg day by day doses divided up into a number of smaller tablets, we required that the berberine dietary supplements in our rankings ship a dose that was simply parsed out into two or three tablets or capsules per day to achieve this clinically efficient dosage vary.

Something with lower than 400 or greater than 600 mg per capsule was dropped from consideration.

High quality elements and no pointless binders or fillers. Past simply the dosage, we additionally seemed on the purity of the berberine dietary supplements. Did they reap the benefits of unbiased laboratory testing for purity, like Nuzena?

Did the capsules have a clear, easy ingredient design, or have been they bloated with silica and different binders or coloring brokers?

These have been the sorts of issues we thought-about when evaluating the remaining berberine dietary supplements. Whereas a cellulose-based capsule versus a gelatin-based capsule was a pleasant perk (for strict vegetarians and vegans), it wasn’t a core analysis standards.

After pooling outcomes from all of those standards, we had our last rankings of the most effective berberine dietary supplements in the marketplace. 


Q: What does berberine do for the physique?

A: Berberine primarily acts in your physique’s metabolic surroundings, serving to to stop the stresses of a poor food regimen and the stresses of being chubby or overweight from inflicting will increase in your blood lipids and blood ldl cholesterol.

It additionally exerts a potent stage of management over poorly regulated blood sugar, which is characteristically seen in sort two diabetes and metabolic syndrome.

These mechanisms are pretty well-researched, however berberine additionally seems to exert some direct advantages on weight reduction, and should have advantages for controlling irritable bowel syndrome as nicely—the reasoning behind why it really works in these functions are much less well-understood.

Q: Can I take berberine and metformin on the identical time?

A: Berberine has been studied together with metformin in a single examine (1), and no unfavorable drug interactions have been reported.

Nevertheless, it’s dangerous to take a prescription remedy and a complement which might be alleged to do the identical factor (i.e. decrease blood sugar) on the identical time, since whether or not these medication work together, or inhibit every others’ mechanism of motion is unknown.

You need to speak to your physician first for those who take metformin (or some other prescription drug) and would additionally prefer to attempt berberine alongside it to raised management your blood sugar.

Q: Can berberine have an effect on testosterone ranges?

A: Some fundamental organic analysis carried out in cells on Petri dishes means that sure sorts of cells (principally tumor cells, or ovary cells) could scale back their expression of testosterone and different androgens, however when it comes to results in your physique general, there’s no proof that berberine will both decrease or increase your testosterone ranges.

Q: How lengthy do you have to take berberine?

A: Medical analysis means that getting the advantages of berberine could take six to eight weeks to attain its results, and several other research have discovered advantages at twelve weeks as nicely.

Past the timeframe of some months, it’s not clear for those who ought to take berberine indefinitely, and any potential long-term well being results haven’t been explored intimately.

Q: Does berberine assist with weight reduction?

A: Some analysis means that berberine could assist with short-term weight reduction, which is nice provided that we already know berberine could be useful at controlling well being points related to being chubby or overweight.

Whereas it’s not as potent of a weight reduction complement as elements like inexperienced tea extract or inexperienced espresso bean extract, the advantages are nonetheless welcome if you’re chubby and are taking berberine for metabolic well being. Simply don’t depend on it to do all the proverbial heavy lifting for you with regards to dropping pounds.

Q: How lengthy does it take for berberine to decrease blood sugar?

A: Most research on berberine for reducing blood sugar have examined their outcomes at six or eight weeks.

That’s to not say that vital variations wouldn’t have emerged if these research have been concluded both, nevertheless it does counsel that you could be wish to be affected person when ready for outcomes from berberine. It’s not essentially going to be a fast in a single day repair, even when it does work.

Associated articles


Berberine has been studied as a pure complement for controlling blood sugar in folks with metabolic syndrome and kind two diabetes.

Furthermore, it has functions in controlling among the different unfavorable results of weight problems, equivalent to excessive blood ldl cholesterol and excessive blood lipids. Whereas berberine reveals some promise as a weight reduction product as nicely, its true power is in controlling the metabolic surroundings in your physique, particularly when it’s pressured by an unhealthy food regimen or carrying round further weight.

Some rising proof even means that berberine could possibly be useful for irritable bowel syndrome, however the causal pathways behind this are usually not but clear.

Berberine is pretty secure, with delicate gastrointestinal unintended effects like constipation and abdomen ache sometimes reported. Berberine seems to be only when taken at dosage ranges of 900 to 1500 mg per day, break up into two to 3 equal doses.

Berberine’s potential for controlling blood sugar, blood lipids, and different indicators of your physique’s metabolic well being is kind of sturdy, making it one of the vital thrilling natural dietary supplements in the marketplace proper now.

For BodyNutrition‘s #1 berberine suggestion, click on right here.